Pii: S1566-2772(01)00005-6
نویسندگان
چکیده
Recent excitement with the human genome project stems partly from the belief that the identi®cation of the genes underlying the nearly 12 000 known genetic disorders will bring us closer to the development of therapies. However, it is still unclear how genetic information can be translated into treatments for inherited disorders. Here, we will review how molecular, physiological and behavioral studies in a mouse model of neuro®bromatosis type I (NF1) have improved our understanding of the learning de®cits associated with this tragically common genetic disorder. We also discuss insights from these studies about the nature and usefulness of animal models of brain disorders. Similar issues are also likely to impact the study of other neurological and psychiatric disorders. q 2001 Association for Research in Nervous and Mental Disease. Published by Elsevier Science B.V. All rights reserved.
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